Dimethyl Sulfoxide → HCID 123644455, compound

Participants

Reaction Conditions

Reaction Steps

1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.41 g, 0.6 mmol) is added to a mixture of tert-butyl-N-{1-[(6-amino-4-bromopyridin-2-yl)carbamoyl]ethyl}-N-methyl-carbamate B1 (5.2 g, 11.2 mmol), bis(neopentyl glycolato)diboron (5.1 g, 22.4 mmol), KOAc (3.3 g, 33.6 mmol) and DMSO (20 ml) under argon atmosphere and the mixture is stirred at 80° C. for 5 h. The mixture is diluted with DCM and extracted with a saturated aqueous sodium hydrogencarbonate solution. The combined organic layers are dried over MgSO4 and concentrated in vacuo. The product is purified by RP HPLC. Yield: 3.2 g (85%). HPLC-MS: M+H=339; tR=0.51 min (Method—2).

Provenance & Evidence