Diisopropylethylamine → HCID 117914857, compound

Participants

Reaction Conditions

Reaction Steps

1H,3H-furo[3,4-c]pyridine-6-carbonyl chloride M1 (33 mg, 0.2 mmol) is added to tert-butyl-N-(1-{[6-amino-4-(6-methylquinolin-5-yl)pyridin-2-yl]carbamoyl}ethyl)-N-methyl-carbamate J1 (60 mg, 0.14 mmol) and DIPEA (59 μl, 0.34 mmol) in THF (1 ml) and the mixture is stirred at 50° C. for 2 h. The mixture is concentrated in vacuo and the product purified by RP HPLC. Yield: 17 mg (21%). HPLC-MS: M+H=583; tR=1.01 min (Method—2).

Provenance & Evidence