HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1772170Generated: October 30, 2026
Toluene → 5-Chloro-3-methylpicolinoyl chloride
https://huagongshe.com/reaction/1772170
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Chloro-3-methylpyridine-2-carboxylic acid | HCID 22392009 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Chloro-3-methylpicolinoyl chloride | HCID 117902519 | — |
Reaction Steps
Thionyl chloride (71 μl, 962 μmol) is added to a mixture of 5-chloro-3-methyl-pyridine-2-carboxylic acid (150 mg, 874 μmol), toluene (1 ml) and DMF (20 μl). The mixture is heated to 60° C. for 1 hour. The mixture is concentrated in vacuo and the crude product used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09249151B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-bbaeffbbde1f46399a97d7b1c1057c54 |
|---|
| Source note | uspto-grants-2016_02 |
|---|
