Ethyl isocyanate → HCID 135875702, compound

Participants

Reaction Steps

The compound of Example 3A (2 g, 8 mmol) and ethyl isocyanate (1.67 g, 24 mmol) were dissolved in pyridine (30 mL) at room temperature. The mixture was warmed, refluxed and stirred overnight. The reaction was stopped. The solvent was rotary-evaporated. A small amount of ethanol was added. A large amount of solids were precipitated. The solids were filtered in vacuo. The solvent was rotary-evaporated. The residue was purified by column chromatography to give 1.618 g of the pure title compound. MS (ESI): m/z 280 (M+H)+

Provenance & Evidence