Cyclohexanone → HCID 89483138, compound

Participants

Reaction Steps

To a 500 mL of reaction flask were added the compound of Example 4C (47.86 g, 159.32 mmol), cyclohexanone (31.27 g, 318.64 mmol) and acetic acid (300 mL). The mixture was heated to 50° C. to 60° C. under nitrogen atmosphere. The reaction was kept overnight. The reaction was stopped and cooled to room temperature. Acetic acid was rotary-evaporated to obtain a crude product. The crude product was separated by column chromatography to give 45.53 g of the title compound as white solid. Yield: 75.1%. MS (ESI): m/z 381 (M+H)+

Provenance & Evidence