Tert-butyl 2-[4-[4-(trifluoromethylsulfonyl)anilino]cyclohexoxy]acetate → 2-[4-[4-(Trifluoromethylsulfonyl) anilino]cyclohexoxy]acetic acid

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Reaction Steps

To a solution of tert-butyl 2-[4-[4-(trifluoromethylsulfonyl) anilino]cyclohexoxy]acetate (0.7 g, 1.6 mmol, 1 eq.) in trifluoroacetic acid (3 mL) was stirred at room temperature for 2 hours. The mixture was concentrated under vacuum to remove excess trifluoroacetic acid. The crude material was dried under high vacuum overnight to obtain 2-[4-[4-(trifluoromethylsulfonyl) anilino]cyclohexoxy]acetic acid as light brown syrup. (0.79 g, 100%); (CI, m/z): [M+H]+ 382; 1H NMR (400 MHz, CD3OD): δ 7.65 (d, J=9.0 Hz, 2H), 6.76 (d, J=9.2 Hz, 2H), 4.13 (s, 2H), 3.37-3.51 (m, 2H), 2.03-2.20 (m, 4H), 1.26-1.54 (m, 4H).

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