Hydrochloric Acid → HCID 67351956, compound

Participants

Reaction Steps

The above prepared (S)-2-((S)-2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-6-tert-butoxycarbonylamino-hexanoic acid benzyl ester (4.516, 6.793 mmol) was dissolved in 4 mol/L HCl in dioxane. After a couple of min, gas evolved and a precipitate was formed. After 3 h at ambient temperature, the reaction mixture was carefully evaporated and scrupulously dried to yield 3.81 g of the title compound as an off-white foam which was used without further purification for Example 7. E. GalNAc Cluster benzyl ester above, MS (ISP) 365.3 [M+H]+.

Provenance & Evidence