Ammonium Chloride → (1S,2R)-4'-(4-Chlorophenyl)-2',3',9'-trimethylspiro[cyclo-propane-1,6'-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine]-2-carboxamide

Participants

Reaction Steps

A procedure analogous to that used for Compound 204 was followed, with the exception that ammonium chloride was used instead of ethylamine hydrochloride. LRMS (M+H)+: 412 m/z. 1H NMR (major conformer reported only) (400 MHz, DMSO-d6) δ 7.38-7.54 (m, 4H), 6.83 (br. s., 1H), 6.69 (br. s., 1H), 2.62 (s, 3H), 2.35 (s, 3H), 2.06 (dd, J=5.04, 8.93 Hz, 1H), 1.93 (t, J=6.20 Hz, 1H), 1.81 (t, J=7.80 Hz, 1H), 1.48 (s, 3H).

Provenance & Evidence