反应详情

温度

170 °C

A mixture of (5-amino-3-methylisothiazol-4-yl)(4-chlorophenyl)methanone (0.19 g, 0.75 mmol) and ethyl 1-aminocyclopropanecarboxylate hydrochloride (0.19 g, 1.13 mmol) in pyridine (1 mL) was heated at 170° C. for 18 h. The reaction mixture was then evaporated, extracted with water, dried over Na2SO4, filtered and evaporated. The crude product was purified by flash chromatography (EtOAc/hexane 0:10 to 5:5) to give 4′-(4-chlorophenyl)-3′-methylspiro[cyclopropane-1,6′-isothiazolo[5,4-e][1,4]diazepin]-7′(8′H)-one (35 mg).

1. customThe reaction mixture was then evaporated
2. extractionextracted with water
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated
6. customThe crude product was purified by flash chromatography (EtOAc/hexane 0:10 to 5:5)