1-(2-Isopropyl-5-methoxyphenyl)thiourea → (1Z)-1-[3-(5-methoxy-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Isopropyl-5-methoxyphenyl)thiourea	HCID 90404099	—
Reactant	3-(4-(1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)propanoyl azide 3-(4-(2-isocyanatoethyl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole	HCID 131732837	—
Product	(1Z)-1-[3-(5-methoxy-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea	HCID 90404292	—

Reaction Steps

The title compound was prepared as described in Example 35 using 3-(4-(1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)propanoyl azide/3-(4-(2-isocyanatoethyl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole (C35b) and 1-(2-isopropyl-5-methoxyphenyl)thiourea (CA40) and isolated as a brown foam (0.040 g, 30%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249133B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-8eb8776abc8b4d408b9b627984b7e2a3
Source note	uspto-grants-2016_02