Methyl 2-bromopropionate → (1Z)-1-[5-methyl-3-(5-methyl-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea

Participants

Role	Name	HCID	Charge
Reactant	Methyl 2-bromopropionate	HCID 95576	—
Reactant	1-(2-Isopropyl-5-methylphenyl)thiourea	HCID 89373168	—
Reactant	3-(4-(2-Isocyanatoethyl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole	HCID 90404408	—
Product	(1Z)-1-[5-methyl-3-(5-methyl-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea	HCID 90404239	—

Reaction Steps

The title compound was prepared from 1-(2-isopropyl-5-methylphenyl)thiourea, 3-(4-(2-isocyanatoethyl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole (C34a), and methyl 2-brompropanoate and isolated as a clear sticky oil (0.192 g, 49%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249133B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-357df44a55dd473faafdc3305ad6f09c
Source note	uspto-grants-2016_02