Sodium Bicarbonate → N-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenethyl)prop-2-en-1-amine
반응식
[CH2:1]([N:4]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:24]=[CH:23][N:22]([C:25]3[CH:30]=[CH:29][C:28]([O:31][C:32]([F:35])([F:34])[F:33])=[CH:27][CH:26]=3)[N:21]=2)=[CH:16][CH:15]=1)C(=O)OC(C)(C)C)[CH:2]=[CH2:3].C(=O)(O)[O-].[Na+]>>[F:35][C:32]([F:33])([F:34])[O:31][C:28]1[CH:27]=[CH:26][C:25]([N:22]2[CH:23]=[N:24][C:20]([C:17]3[CH:18]=[CH:19][C:14]([CH2:13][CH2:12][NH:4][CH2:1][CH:2]=[CH2:3])=[CH:15][CH:16]=3)=[N:21]2)=[CH:30][CH:29]=1참가 물질
3
실험 절차
The title compound was prepared from tert-butyl allyl(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenethyl)carbamate (CB65), neutralized with aqueous sodium bicarbonate, and isolated as a yellow solid (0.124 g, 90%): mp 110-120° C.; 1H NMR (400 MHz, CDCl3) δ 8.54 (s, 1H), 8.14-8.07 (m, 2H), 7.81-7.73 (m, 2H), 7.42-7.34 (m, 2H), 7.34-7.28 (m, 2H), 5.92 (ddt, J=16.9, 10.2, 6.6 Hz, 1H), 5.43-5.22 (m, 2H), 3.49 (dt, J=6.6, 1.2 Hz, 2H), 3.19-2.92 (m, 5H); 19F NMR (376 MHz, CDCl3) δ −58.04; ESIMS m/z 389 ([M+H]+).
출처 및 근거
- ORD 기록
- ord-dc328ce4f890448597d2a6587dd000fb
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09249133B2
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