1-(2-Isopropyl-4-methylphenyl)thiourea → 1-[(2-isopropyl-4-methyl-phenyl)carbamothioyl]-3-[[3-[1-[4-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-3-yl]phenyl]methyl]urea

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Isopropyl-4-methylphenyl)thiourea	HCID 89373113	—
Reactant	3-(3-(isocyanatomethyl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole	HCID 90412150	—
Product	1-[(2-isopropyl-4-methyl-phenyl)carbamothioyl]-3-[[3-[1-[4-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-3-yl]phenyl]methyl]urea	HCID 90412823	—

Reaction Steps

The title compound was prepared as described in Example 75 using 3-(3-(isocyanatomethyl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole (CB34) and 1-(2-isopropyl-4-methylphenyl)thiourea and isolated as an off-white solid (0.216 g, 50%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249133B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-92425c5a4e2e4f56bce7d75c57fb57c9
Source note	uspto-grants-2016_02