Ethyl 8-morpholinoimidazo[1,2-a]pyrazine-2-carboxylate → (8-Morpholinoimidazo[1,2-a]pyrazin-2-yl)methanol

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Reaction Steps

To a solution of compound 1c (8.40 g, 30.4 mmol) in THF (100 mL) was added LiAlH4 (2.55 g, 60.8 mmol) in portions at 0° C. The reaction mixture was stirred at rt for 2 h. The reaction was slowly quenched with H2O (10 mL). The resulting mixture was extracted with DCM (2×100 mL), and the combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to obtain compound 1d as a yellow solid (3.80 g, 53% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C11H14N4O2: 235.1 (M+H). found: 235.2.

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