2-Cyanopyridine-5-boronic acid pinacol ester → 5-(8-Morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-a]pyrazin-5-yl) picolinonitrile

Participants

Reaction Steps

Compound 3a (950 mg, 2.17 mmol) was subjected to Suzuki coupling conditions with compound 1f (prepared in Example 1, Step F) as described in Example 1, Step G to obtain compound 3b as a white solid (820 mg, 82% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C27H23N7O: 462.2 (M+H). found: 462.2.

Provenance & Evidence