Water → HCID 86345983, compound

Participants

Reaction Steps

A solution of compound 5a (180 mg, 0.370 mmol) in formic acid (3 mL) was stirred in a 10 mL sealed tube at 100° C. for 2 h. After cooling to rt, water (20 mL) was added, and the pH of the solution was adjusted to 7 with saturated NaHCO3 solution. The resulting solids were collected by filtration and washed with Et2O to obtain the title compound 91 as a yellow solid (37 mg, 19% yield). 1H-NMR (300 MHz, DMSO-d6+D2O) δ (ppm): 8.96 (s, 1H), 8.72 (d, J=8.4 Hz, 1H), 8.38-8.32 (m, 4H), 8.19-8.06 (m, 4H), 8.01-7.91 (m, 1H), 7.74-7.68 (m, 2H), 7.58 (s, 1H), 4.45-4.25 (m, 4H), 3.90-3.70 (m, 4H). Mass Spectrum (LCMS, ESI pos.): Calcd. for C28H23N9O: 502.2 (M+H). Found 502.3.

Provenance & Evidence