Trifluoroacetic acid methylene chloride → HCID 117728225, compound

Participants

Reaction Steps

A solution of compound 13b (200 mg, 0.300 mmol) in DCM/TFA (4:1 v/v, 10 mL) was stirred at rt for 30 min. Solvent was evaporated, and water (5 mL) was added. The resulting solids were collected by filtration and washed with Et2O to obtain the title compound as a yellow solid (40.2 mg, 25% yield). 1H-NMR (300 MHz, DMSO-d6) δ (ppm): 8.44 (d, J=8.7 Hz, 1H), 8.29-8.23 (m, 1H), 8.18 (s, 1H), 8.03-7.91 (m, 4H), 7.85-7.73 (m, 2H), 7.71 (s, 1H), 7.65-7.52 (m, 2H), 7.51-7.40 (m, 1H), 7.38 (s, 1H), 6.85 (d, J=8.4 Hz, 1H), 4.40-4.20 (m, 4H), 4.18-4.01 (m, 2H), 3.93-3.77 (m, 4H). Mass Spectrum (LCMS, ESI pos.): Calcd. for C28H25N7O3: 508.2 (M+H). Found 508.3.

Provenance & Evidence