反应详情

To a solution of compound 1c (3.2 g, 9.0 mmol) in DCM (100 mL) at 0° C. was added NBS (1.6 g, 9.0 mmol) portionwise. The reaction mixture was allowed to stir at rt for 10 min, and subsequently was washed with a saturated aqueous sodium bicarbonate (2×100 mL). The organic layer was separated, dried over Na2SO4 and concentrated under reduced pressure to give compound 21a as an off-white solid. Mass Spectrum (LCMS, ESI pos.) Calcd. For C13H15BrN4O3: 356.2 (M+H). Found 356.1.

1. washsubsequently was washed with a saturated aqueous sodium bicarbonate (2×100 mL)
2. customThe organic layer was separated
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under reduced pressure