2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 117732274, compound

Participants

Reaction Conditions

Reaction Steps

A microwave vial was charged with compound 24d (154 mg, 0.840 mmol), compound 24c (350 mg, 0.700 mmol), sodium tert-butoxide (94.1 mg, 0.980 mmol), Pd2(dba)3 (12.8 mg, 0.0140 mmol), and 2-(dicyclohexylphosphino)-2′,4′,6′-tri-isopropyl-1,1′-biphenyl (26.6 mg, 0.0560 mmol) and purged with Argon gas. Toluene (3 mL) was then added and the resulting mixture was heated in a microwave at 120° C. for 1 h. The reaction mixture was allowed to cool to rt, diluted with water (20 mL) and EtOAc (20 mL). The organic layer was separated, dried over Na2SO4, filtered, and concentrated. The residue obtained was purified by flash column chromatography on silica gel (1:0-1:4 heptane/EtOAc) to obtain compound 24e. Mass Spectrum (LCMS, ESI pos.) Calcd. for C36H41N9O3: 648.3 (M+H). Found 648.4.

Provenance & Evidence