Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate → tert-Butyl 4-(2-(hydroxymethyl)-8-morpholinoimidazo[1,2-a]pyrazin-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Participants

Reaction Steps

Compound 1e was subjected to Suzuki coupling reaction conditions with N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester using the method described in Example 1, Step G to obtain compound 26a. Mass Spectrum (LCMS, ESI pos.) Calcd. for C21H29N5O4: 416.2 (M+H). Found 416.3.

Provenance & Evidence