N-bromobutanimide → HCID 117732281, compound

HRID 1772652Notes

Reaction equation

HRID 1772652 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]3[N:9]([CH:13]=[C:14]([CH:16]4[CH2:19][N:18]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:17]4)[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH2:3][CH2:2]1.C1C(=O)N([Br:34])C(=O)C1>>[Br:34][C:10]1[N:9]2[CH:13]=[C:14]([CH:16]3[CH2:19][N:18]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:17]3)[N:15]=[C:8]2[C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[N:12][CH:11]=1

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 117732280tert-Butyl 3-(8-morpholinoimidazo[1,2-a]pyrazin-2-yl)azetidine-1-carboxylate

Product 1

HCID 117732281HCID 117732281, compound

Procedure

Compound 29a was brominated with NBS using the methods described in Example 1, Step E to obtain compound 29b. Mass Spectrum (LCMS, ESI pos.): Calcd. for C18H24BrN5O3: 438.1 (M+H). found: 438.2.

Sources & evidence

ORD record
ord-e0bfa79906014af99946849343a5be9b
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

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