反应详情

Compound 31b was subjected to Suzuki coupling reaction conditions with (4-(1H-tetrazol-5-yl)phenyl)boronic acid using the methods described in Example 1, Step G to obtain compound 31c. 1H-NMR (400 MHz, DMSO-d6) 8.26 (d, J=8.6 Hz, 1H), 8.21 (d, J=8.6 Hz, 2H), 8.17 (s, 1H), 7.88-7.93 (m, 3H), 7.80 (d, J=8.6 Hz, 1H), 7.65-7.71 (m, 1H), 7.55 (s, 1H), 7.45 (t, J=7.0 Hz, 1H), 7.06 (d, J=9.0 Hz, 1H), 5.58 (s, 2H), 4.21-4.28 (m, 4H), 3.75-3.80 (m, 4H). Mass Spectrum (LCMS, ESI pos.) Calcd. for C27H23N9O2: 506.2 (M+H). Found 506.2.