HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-(N-(2-((tert-Butyldimethylsilyl)oxy)ethyl)sulfamoyl)phenyl)boronic acid → (E)-N-(2-((tert-Butyldimethylsilyl)oxy)ethyl)-4-(8-morpholino-2-(2-(quinolin-2-yl)vinyl)imidazo[1,2-a]pyrazin-5-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-(N-(2-((tert-Butyldimethylsilyl)oxy)ethyl)sulfamoyl)phenyl)boronic acid | HCID 44119854 | — |
| Reactant | (E)-4-(5-Bromo-2-(2-(quinolin-2-yl)vinyl)imidazo[1,2-a]pyrazin-8-yl)morpholine | HCID 117728505 | — |
| Product | (E)-N-(2-((tert-Butyldimethylsilyl)oxy)ethyl)-4-(8-morpholino-2-(2-(quinolin-2-yl)vinyl)imidazo[1,2-a]pyrazin-5-yl)benzenesulfonamide | HCID 131734677 | — |
Reaction Steps
Compound 2b was subjected to Suzuki coupling reaction conditions as described in Example 1, Step G, with (4-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)phenyl)boronic acid to obtain compound 33a. Mass Spectrum (LCMS, ESI pos.) Calcd. For C35H42N6O4SSi: 671.3 (M+H). Found 671.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249163B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-9c48ccdb5876402f81ccaa06a62b0485 |
| Source note | uspto-grants-2016_02 |