HRID1772666

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Brc1cnc(N2CCOCC2)c2nc(CCc3ccc4ccccc4n3)cn12

HCID117727895

未命名化合物

结构：CC1(C)OB(c2ccc3c(c2)C(F)(F)C(=O)N3COCC[Si](C)(C)C)OC1(C)C

HCID118998233

未命名化合物

PRODUCTS

生成物

结构：C[Si](C)(C)CCOCN1C(=O)C(F)(F)c2cc(-c3cnc(N4CCOCC4)c4nc(CCc5ccc6ccccc6n5)cn34)ccc21

HCID131734679

未命名化合物

PROCEDURE

实验过程

Compound 3a was subjected to Suzuki coupling conditions with 3,3-difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2(trimethylsilyl)ethoxy)methyl)indolin-2-one to obtain compound 37b using the method described in the Example 21, Step D. Mass Spectrum (LCMS, ESI pos.) Calcd. For C35H38F2N6O3Si: 657.2 (M+H). Found 657.5.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-68bae188b37e481f9de5ebedfc7a96ff
来源数据集: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09249163B2
来源说明: uspto-grants-2016_02

反应 SMILES

Br[C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH2:12][C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[N:14]=3)[N:10]=[C:6]2[C:5]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[N:4][CH:3]=1.[F:29][C:30]1([F:57])[C:38]2[C:33](=[CH:34][CH:35]=[C:36](B3OC(C)(C)C(C)(C)O3)[CH:37]=2)[N:32]([CH2:48][O:49][CH2:50][CH2:51][Si:52]([CH3:55])([CH3:54])[CH3:53])[C:31]1=[O:56]>>[F:29][C:30]1([F:57])[C:38]2[C:33](=[CH:34][CH:35]=[C:36]([C:2]3[N:7]4[CH:8]=[C:9]([CH2:11][CH2:12][C:13]5[CH:22]=[CH:21][C:20]6[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=6)[N:14]=5)[N:10]=[C:6]4[C:5]([N:23]4[CH2:24][CH2:25][O:26][CH2:27][CH2:28]4)=[N:4][CH:3]=3)[CH:37]=2)[N:32]([CH2:48][O:49][CH2:50][CH2:51][Si:52]([CH3:55])([CH3:53])[CH3:54])[C:31]1=[O:56]