Trifluoroacetic acid → HCID 117727721, compound

Participants

Reaction Steps

Compound 2b was subjected to Suzuki coupling conditions using the methods described in Example 1, Step G, with compound 40b and the resulting product was deprotected with TFA at 70° C. for 30 min. The reaction mixture was allowed to cool to rt and concentrated. The residue obtained was dried under reduced pressure overnight, suspended in ETOAc (10 mL) and sonicated for 10 min. The solid formed was collected by suction filtration and dried under reduced pressure to obtain the title compound 24. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 8.67-8.78 (m, 1H), 8.04-8.23 (m, 7H), 7.88-7.98 (m, 1H), 7.65-7.78 (m, 3H), 7.51 (s, 1H), 4.33 (br. s., 4H), 3.78-3.91 (m, 4H), 3.51 (s, 3H).

Provenance & Evidence