HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 2-[[8-(4-Morpholinyl)-5-(3-pyridinyl)imidazo[1,2-a]pyrazin-2-yl]methoxy]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 2734656 | — |
| Reactant | HCID 117728336 | HCID 117728336 | — |
| Product | 2-[[8-(4-Morpholinyl)-5-(3-pyridinyl)imidazo[1,2-a]pyrazin-2-yl]methoxy]quinoline | HCID 86345768 | — |
Reaction Steps
Compound 15a (150.0 mg, 0.34 mmol) was subjected to Suzuki coupling conditions with 3-pyridineboronic acid pinacol ester using the methods described in Example 1, Step G to obtain compound 46a. Mass Spectrum (LCMS, ESI pos.) Calcd. for C25H22N6O2: 439.1 (M+H). Found 439.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249163B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-afbf589ab45c4743afb3aac3230cb4bb |
| Source note | uspto-grants-2016_02 |