Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate → HCID 117732287, compound

HRID 1772693Notes

Reaction equation

HRID 1772693 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[N:13]3[CH:14]=[C:15]([CH2:17][O:18][C:19]4[CH:28]=[CH:27][C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[N:20]=4)[N:16]=[C:12]3[C:11]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[N:10][CH:9]=2)=[CH:4][CH:3]=1.[C:35]([N:42]1[CH2:47][CH:46]=[C:45](B2OC(C)(C)C(C)(C)O2)[CH2:44][CH2:43]1)([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36]>>[O:32]1[CH2:33][CH2:34][N:29]([C:11]2[C:12]3[N:13]([CH:14]=[C:15]([CH2:17][O:18][C:19]4[CH:28]=[CH:27][C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[N:20]=4)[N:16]=3)[C:8]([C:5]3[CH:4]=[CH:3][C:2]([C:45]4[CH2:46][CH2:47][N:42]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:43][CH:44]=4)=[N:7][CH:6]=3)=[CH:9][N:10]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 4642098Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylateHCID 117728148HCID 117728148, compound

Product 1

HCID 117732287HCID 117732287, compound

Procedure

Compound 49b was prepared from compound 49a and N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester using the methods described in Example 1, Step G. Mass Spectrum (LCMS, ESI pos.) Calcd. For C35H37N7O4: 620.4 [M+H]. found 620.3.

Sources & evidence

ORD record
ord-6f4c0400513f494facff3d7a9764a402
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

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