Dimethylformamide → HCID 86345858, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 31b (200 mg, 0.450 mmol), zinc cyanide (106 mg, 0.910 mmol), Pd(PPh3)4 (105 mg, 0.910 mmol) in DMF (5 mL) was heated to 80° C. for 4 h. The reaction was cooled to rt, filtered through a diatomaceous earth cartridge (2.5 g), and the filter cake was rinsed with EtOAc. The combined organic layers were concentrated under reduced pressure. The residue was recrystallized with hot EtOAc, collected by filtration, and dried to give compound 55a. Mass Spectrum (LCMS, ESI pos.) Calcd. for C21H18N6O2: 387.2 [M+H]. found 387.2

Provenance & Evidence