Sodium Carbonate → HCID 131734685, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 2b (100 mg, 0.229 mmol), compound 82c (115 mg, 0.275 mmol), PdCl2(dppf)-DCM (5.6 mg, 0.0069 mmol), and Argon-degassed aqueous 2M Na2CO3 (0.573 mL, 1.15 mmol) in Argon-degassed 1,4-dioxane (4 mL) was further degassed with Argon for 3 min and then stirred at 90° C. for 5 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure to a brown oil which was purified by flash column chromatography on silica gel (20-100% EtOAc-DCM), followed by a second purification by flash column chromography for mixed fractions (0-80% EtOAc-DCM), to afford compound 83a as a pale yellow solid. Mass spectrum (LCMS, ESI pos.): Calcd. for C35H38N8O3Si, 647.3 (M+H). found 647.7.

Provenance & Evidence