Sodium Carbonate → HCID 123984127, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 3a (102 mg, 0.233 mmol), compound 84d (97.1 mg, 0.233 mmol, PdCl2(dppf)-DCM (5.7 mg, 0.0070 mmol), and Ar-degassed aqueous 2M Na2CO3 (0.582 mL, 1.16 mmol) in Argon-degassed 1,4-dioxane (4 mL) was further degassed with Argon for 3 min and then stirred at 90° C. for 5 h. After cooling to rt, the reaction mixture was concentrated under reduced pressure to a brown oil which was purified by flash column chromatography on silica gel (40-100% EtOAc-DCM, followed by 100% EtOAc) to afford compound 84e as a crystalline white solid. Mass spectrum (LCMS, ESI pos.): Calcd. for C35H40N8O3Si, 649.3 (M+H). found 649.6.

Provenance & Evidence