Trifluoroacetic acid → HCID 117728020, compound

Participants

Reaction Steps

To a mixture of compound 87e (60.0 mg, 0.0976 mmol) in 3 mL of DCM at rt was added TFA (0.50 mL). The resulting mixture was stirred at rt for 1 h. The solvent was removed under reduced pressure and the residue was triturated with Et2O. The solid was collected by filtration and washed with Et2O. After drying under reduced pressure, the title compound 120 was obtained as an orange solid. 1H-NMR (CD3OD; 400 MHz) 9.36 (d, J=6.1 Hz, 2H), 8.92 (d, J=6.1 Hz, 2H), 8.62 (s, 1H), 8.30 (s, 1H), 8.05-8.20 (m, 3H), 7.82 (t, J=7.3 Hz, 2H), 7.66 (t, J=7.8 Hz, 1H), 7.43 (t, J=7.3 Hz, 1H), 7.14 (d, J=8.8 Hz, 1H), 7.01 (d, J=8.8 Hz, 1H), 5.82 (s, 2H), 3.96-4.04 (m, 4H), 3.34-3.41 (m, 4H). Mass spectrum (LCMS, ESI pos.): Calcd. for C30H26N8O, 515.2 (M+H). found 515.2.

Provenance & Evidence