Piperazine → 1-(5-Bromopyridin-2-yl)piperazine

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-2-chloropyridine (110 g, 573 mmol) and piperazine (99.1 g, 1.15 mol) was stirred overnight at 130° C. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in water (200 mL) and then extracted with DCM (3×200 mL). The combined organic layers were concentrated under reduced pressure to obtain compound 90a as a white solid (105 g, 76% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C9H12BrN3: 242.0 (M+H). found 242.0.

Provenance & Evidence