3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester → HCID 117727985, compound

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Reaction Steps

Compound 90g (1.08 g, 2.10 mmol) was subjected to Suzuki coupling with 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane using the method described in Example 87, Step D to obtain compound 90h as a yellow solid (520 mg, 44% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C28H34N6O5: 535.3 (M+H). found: 535.6.

Provenance & Evidence