HCID 117727985, compound → HCID 117728130, compound

HRID 1772751Notes

Reaction equation

HRID 1772751 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([C:20]3[N:25]4[CH:26]=[C:27]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[N:28]=[C:24]4[C:23]([C:34]4[CH2:35][CH2:36][O:37][CH2:38][CH:39]=4)=[N:22][CH:21]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([C:20]3[N:25]4[CH:26]=[C:27]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[N:28]=[C:24]4[C:23]([CH:34]4[CH2:39][CH2:38][O:37][CH2:36][CH2:35]4)=[N:22][CH:21]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 117727985HCID 117727985, compound

Product 1

HCID 117728130HCID 117728130, compoundYield 104.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
35 °C

Procedure

A solution of compound 90h (470 mg, 0.830 mmol) in MeOH (2 mL) and 10% palladium on carbon (300 mg) was placed under a H2 atmosphere using a H2 balloon. The reaction mixture was stirred overnight at 35° C. A solid was removed by filtration. The filtrate was concentrated under reduced pressure to obtain compound 90i as a gray solid (465 mg, 99% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C28H36N6O5: 537.3 (M+H). found: 537.6.

Workup

  1. customA solid was removed by filtration
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-06539e7db02b45eb894148016d8c3f91
Source dataset
uspto-grants-2016_02
Patent number
US09249163B2

Reaction notes

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