Trifluoroacetic acid → HCID 117728069, compound

Participants

Reaction Steps

Compound 91a (130 mg, 0.210 mmol) was treated with TFA as described in Example 87, Step F to obtain the title compound 83 as a light yellow solid (61.7 mg, 55% yield). 1H-NMR (300 MHz, DMSO-d6) δ (ppm): 8.84 (s, 1H), 8.51 (s, 1H), 8.27 (d, J=9.0 Hz, 1H), 8.13 (s, 1H), 8.03 (dd, J=2.4 Hz, 8.7 Hz, 1H), 7.90 (d, J=8.1 Hz, 1H), 7.86 (s, 1H), 7.81 (d, J=8.7 Hz, 1H), 7.72-7.67 (m, 1H), 7.49-7.44 (m, 1H), 7.12 (d, J=9.0 Hz, 1H), 7.07 (d, J=9.0 Hz, 1H), 5.65 (s, 2H), 4.03-4.00 (m, 2H), 3.87-3.78 (m, 5H), 3.61-3.54 (m, 2H), 3.28-3.20 (m, 4H), 2.01-1.87 (m, 4H). Mass Spectrum (LCMS, ESI pos.) Calcd. for C30H31N7O2: 522.3 (M+H). Found 522.3.

Provenance & Evidence