Hydrochloric Acid → 4-piperazin-1-yl-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile hydrochloride

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Reaction Steps

tert-Butyl 4-{3-cyano-2-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}piperazine-1-carboxylate (second peak from chiral purification, 0.70 g, 0.0012 mol) was stirred with 4.0 M of hydrogen chloride in p-dioxane (5.0 mL, 0.020 mol) at RT for 30 min. After evaporating to dryness, the resulting HCl salt was used directly in next step. LCMS calculated for C23H34N9OSi(M+H)+: m/z=467.3; Found: 467.0.

Provenance & Evidence