Hydrochloric Acid → HCID 67054933, compound

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Reaction Steps

tert-Butyl 4-{3-cyano-2-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}piperidine-1-carboxylate (second peak from chiral purification, 1.12 g, 0.00198 mol) was stirred with 4.0 M of hydrogen chloride in p-dioxane (5 mL, 0.02 mol) at RT for 30 min. After being concentrated to dryness under reduced pressure, the resultant HCl salt was used directly in next step. LCMS calculated for C24H36N7OSi(M+H)+: m/z=466.3; Found: 466.2.

Provenance & Evidence