Methanesulfonyl chloride → HCID 86651906, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of benzyl 4-(2-hydroxypropyl)piperazine-1-carboxylate (from step 1, 1.7 g, 6.1 mmol) in DCM (20 mL) was added DIPEA (2.1 mL, 12 mmol) followed by methanesulfonyl chloride (0.70 mL, 9.0 mmol) at 0° C. The reaction was stirred at 0° C. for 2 h. The reaction was quenched with saturated NaHCO3 solution and extracted with DCM. The combined organic layers were washed with brine, dried over MgSO4 and concentrated to provide crude product (2.22 g) which was used in next step without further purification. LCMS calculated for C16H25N2O5S(M+H)+: m/z=357.1; Found: 357.3.

Provenance & Evidence