Benzyl piperazine-1-carboxylate → HCID 67054979, compound

Participants

Reaction Steps

To the crude 3-fluoro-2-hydroxypropyl 4-methylbenzenesulfonate (1.98 g, 7.98 mmol) in methanol (40 mL) was added benzyl piperazine-1-carboxylate (1.76 g, 7.98 mmol). The reaction was stirred at RT over the weekend. After being evaporated to dryness, the residue was purified on silica gel, eluting with 0 to 10% MeOH in DCM to yield the desired product (443 mg, 18.7%). LCMS calculated for C15H22FN2O3(M+H)+: m/z=297.2; Found: 297.4.

Provenance & Evidence