Hydrochloric Acid → HCID 67054921, compound

Participants

Reaction Steps

4.0 M of HCl in p-dioxane (3.0 mL, 0.012 mol) was added to a solution of diastereomeric tert-butyl (3R)-4-{3-cyano-2-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-methylpiperazine-1-carboxylate (0.50 g, 0.86 mmol) in 1,4-dioxane (5 mL). The reaction was stirred at room temperature for 80 minutes. Solvent was removed in vacuo to afford the product as a mixture of diastereomers and as the hydrochloride salt (470 mg, 98%). LCMS (M+H)+: 481.3.

Provenance & Evidence