Hydrochloric Acid → HCID 67055034, compound

Participants

Reaction Steps

4.0 M of hydrogen chloride in p-dioxane (1.6 mL, 6.4 mmol) was added to a solution of tert-butyl 3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-{3-cyano-2-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}piperazine-1-carboxylate (0.32 g, 0.45 mmol, a mixture of diastereomers from Step 3) in 1,4-dioxane (2 mL). After stirring for 80 min, solvent was removed from the mixture in vacuo to afford the product as a light yellow solid, which was used without further purification (270 mg). LCMS (M+H)+: 497.2.

Provenance & Evidence