Hydrochloric Acid → HCID 67055049, compound

Participants

Reaction Steps

A solution of tert-butyl 4-{3-cyano-2-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}-3-(methoxymethyl)piperazine-1-carboxylate (91 mg, 0.10 mmol, as a mixture of diastereomers from Step 3) in 1,4-dioxane (0.6 mL) was treated with 4.0 M of hydrogen chloride in p-dioxane (0.50 mL, 2.0 mmol). After the mixture was stirred at RT for 80 min, solvent was removed in vacuo to afford product which was used without purification in Step 5. LCMS (M+H)+: 511.2.

Provenance & Evidence