HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide → 2-amino-N-(6-methoxy-5-methylpyridin-3-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide | HCID 90022532 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | 2-amino-N-(6-methoxy-5-methylpyridin-3-yl)benzenesulfonamide | HCID 90030717 | 106.5% |
Reaction Steps
A mixture of N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide (2.69 g, 8.32 mmol) and 10% palladium on charcoal (1.35 g) in ethanol/EtOAc (1:1, 100 mL total reaction volume) was stirred at rt under an atmosphere of H2 for approximately 2.5 h. Filtration and concentration in vacuo yielded the crude title compound (2.60 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249160B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-886338baa49241c6a370f08fa640ef18 |
| Source note | uspto-grants-2016_02 |