HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorobenzenesulphonyl chloride → 2-Fluoro-N-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorobenzenesulphonyl chloride | HCID 137761 | — |
| Reactant | 5-Amino-1-methyl-1,2-dihydropyridin-2-one | HCID 10220005 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 2-Fluoro-N-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzenesulfonamide | HCID 47298840 | 82.6% |
Reaction Steps
2-Fluorobenzenesulfonyl chloride (0.46 mL, 3.5 mmol) was added to a solution of 5-amino-1-methyl-1,2-dihydropyridin-2-one (478 mg, 3.85 mmol) in 1,4-dioxane (10 mL) and stirred for 28 h at rt. After concentration in vacuo purification by column chromatography eluting with DCM:MeOH:7M NH3 in MeOH (90:5:5) yielded the title compound (448 mg, 1.59 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249160B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-fab72010499b416091a1aafb64c5aa9b |
| Source note | uspto-grants-2016_02 |