HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-(methylthio)- → HCID 90022642, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-(methylthio)- | HCID 15693 | — |
| Reactant | 2-Chloro-6-fluorobenzylamine | HCID 84833 | — |
| Reactant | 2,5-Difluorobenzenesulfonyl chloride | HCID 2736911 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 90022642 | HCID 90022642 | 5.2% |
Reaction Steps
The title compound (119 mg, 0.26 mmol) was prepared in two steps from 2,5-difluorobenzenesulfonyl chloride (1.07 g, 5.0 mmol) and 3-(methylsulfanyl)aniline (769 mg, 5.5 mmol) in 1,4-dioxane at 70° C.; followed by 2-chloro-6-fluorobenzyl amine (762 uL, 5.9 mmol) in MeCN (1.5 mL) at 180° C. in a Biotage Initiator microwave reactor using the methods of (IntB1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249160B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-e21174be3c954af7bc29d2e2b1668e16 |
| Source note | uspto-grants-2016_02 |