HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-3-pyridinylamine → HCID 90021835, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-3-pyridinylamine | HCID 81121 | — |
| Reactant | 2-Chloro-6-fluorobenzylamine | HCID 84833 | — |
| Reactant | 2,3-Difluorobenzene-1-sulfonyl chloride | HCID 21869065 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 90021835 | HCID 90021835 | 9.4% |
Reaction Steps
The title compound (139 mg, 0.32 mmol) was prepared in two steps from 2,3-difluorobenzenesulfonyl chloride (1.0 g, 4.7 mmol) and 6-methoxypyridin-3-amine (642 mg, 5.2 mmol) in 1,4-dioxane at 100° C.; followed by 2-chloro-6-fluorobenzyl amine (547 mg, 3.4 mmol) in MeCN (3 mL) at 180° C. in a Biotage Initiator microwave reactor using the methods of (IntB1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249160B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-091cccd48ce646e099af78d86748babc |
| Source note | uspto-grants-2016_02 |