Pyridine → 2-Chloro-N-(5,6-dimethoxypyridin-3-yl)pyridine-3-sulfonamide

HRID 1772904Notes

Reaction equation

HRID 1772904 reaction equation
[Cl:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([NH2:22])[CH:17]=[N:18][C:19]=1[O:20][CH3:21].N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[C:7]([S:8]([NH:22][C:16]2[CH:17]=[N:18][C:19]([O:20][CH3:21])=[C:14]([O:13][CH3:12])[CH:15]=2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 127582145,6-Dimethoxypyridin-3-amine

Product 1

HCID 900214752-Chloro-N-(5,6-dimethoxypyridin-3-yl)pyridine-3-sulfonamideYield 65.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound (542 mg, 1.64 mmol) was prepared from 2-chloropyridine-3-sulfonyl chloride (530 mg, 2.5 mmol), 5,6-dimethoxypyridin-3-amine (424 mg, 2.8 mmol) and pyridine (0.6 mL, 7.5 mmol) in DCM (10 mL) using the methods of (IntC1).

Sources & evidence

ORD record
ord-a4a0ac3107fe45089f5bfe4cd71f8a54
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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