Pyridine → HCID 90022597, compound

HRID 1772917Notes

Reaction equation

HRID 1772917 reaction equation
[Cl:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([NH2:21])[CH:17]=[N:18][C:19]=1[CH3:20].N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[C:7]([S:8]([NH:21][C:16]2[CH:17]=[N:18][C:19]([CH3:20])=[C:14]([O:13][CH3:12])[CH:15]=2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 20612511HCID 20612511, compound

Product 1

HCID 90022597HCID 90022597, compoundYield 16.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound (117 mg, 0.372 mmol) was prepared from 2-chloropyridine-3-sulfonyl chloride (469 mg, 2.2 mmol), 5-methoxy-6-methylpyridin-3-amine (336 mg, 2.4 mmol) and pyridine (0.54 mL, 7.5 mmol) in DCM (9 mL) at 0° C. to rt using the methods of (IntC1).

Sources & evidence

ORD record
ord-5872a10c8cfa43b1b2363859e6f6339d
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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