(3,5-Difluoropyridin-4-yl)methanol → HCID 72721483, compound

HRID 1772936Notes

Reaction equation

HRID 1772936 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:10])[C:7]=1[CH2:8]O.ClC1C=C(OC)C=C(F)C=1C[N:15]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[S:18](=[O:26])(=[O:25])[N:17]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=2)[C:16]1=[O:37]>>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][N:15]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[S:18](=[O:26])(=[O:25])[N:17]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=2)[C:16]1=[O:37]

Participants

3

Reactant 2

HCID 66815317(3,5-Difluoropyridin-4-yl)methanolHCID 72722084HCID 72722084, compound

Product 1

HCID 72721483HCID 72721483, compound

Procedure

The title compound (47 mg, 0.10 mmol) was prepared from (IntA1) (167 mg, 0.50 mmol) and 3,5-difluoropyridine-4-methanol (109 mg, 0.75 mmol) using the methods of (113).

Sources & evidence

ORD record
ord-de75d868eeab4d09a4d1d0c3022afed6
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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