Potassium Carbonate → 4-(4-Chloro-2-fluorobenzyl)-2-(3,4-dimethoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

HRID 1772944ノート

反応式

HRID 1772944 の反応式
[C:1]([O-])([O-])=[O:2].[K+].[K+].[Cl:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Br)=[C:10]([F:16])[CH:9]=1.[CH3:17][O:18][C:19]1[C:24](C)=[CH:23][C:22]([N:26]2[C:31](=[O:32])[N:30](CC3C(F)=CC(F)=CC=3F)[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27]2(=[O:48])=[O:47])=[CH:21][C:20]=1C>CN(C=O)C>[Cl:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12][N:30]2[C:29]3[CH:43]=[CH:44][CH:45]=[CH:46][C:28]=3[S:27](=[O:47])(=[O:48])[N:26]([C:22]3[CH:21]=[CH:20][C:19]([O:18][CH3:17])=[C:24]([O:2][CH3:1])[CH:23]=3)[C:31]2=[O:32])=[C:10]([F:16])[CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 27365514-Chloro-2-fluorobenzyl bromideHCID 727220852-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

生成物 1

HCID 727210814-(4-Chloro-2-fluorobenzyl)-2-(3,4-dimethoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound (43 mg, 0.09 mmol) was prepared from (IntA1) (50 mg, 0.15 mmol), K2CO3 (62 mg, 0.45 mmol) and 4-chloro-2-fluorobenzyl bromide (40 mg, 0.18 mmol) in DMF (2 mL) using the methods of (115).

出典と根拠

ORDレコード
ord-810c1655257d438380a70faff87fe799
出典データセット
uspto-grants-2016_02
特許番号
US09249160B2

反応ノート

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